One of the common mistakes in constructing software that is sub-par with requirements is the lack of understanding of the domain in which it is to be operated. This fallout or mis-communication is perpetrated evidently by usage of different types of languages between the developers and domain experts (abstracted for the sake of simplicity) Evaluation of failures have enabled us to realize that underestimation of domain can lead into perils in project understanding. One of popular example occurs when you try to apply simple CRUD generators into, say something like medical instrumentation. Your productivity falls and you end up hitting a wall. This is evident as the technology is just the enabler, and not the end to means. I have learnt this the hard way in one of my recent project where over engineering and legacy code forced us to create entity framework configuration files via a self-created generator instead of the inbuilt edmx designer - an example of relying on reverse engineering over traditional process.
However, many software solutions which are designed with their domain in mind are essentially an object-oriented model expressed in terms of their domain, at its core. The domain, rather than data-oriented entities constitute this and it compasses the domain wisdom (logic, data, rules, terminology) expressed in simple and utilizable manner. One of the tangible benefits of utilizing this approach is that this increases the longevity of code as domain outlives its implementation. Moreover, this can be modularized into reusable components and mashed-up as the needs arise.
But to start off with, in existing applications, we can use metadata such as annotations or attributes to 'beautify' our code through using the domain logic without undergoing any unnecessary plumbing in the existing application architecture/stack. Another benefit from using them is that in java or c# multiple inheritance is not possible, but this can exist in the domain.
One thing that most domain-oriented tools tend to do is interface their data/stack through xml, which might be fine for domain experts, but is pain to maintain (think of all the xml documents for business rules and instances).
Thus domain annotations provide a starting point of integrating domain knowledge into our code, making it more reasonable. Other approaches include use of full fledged frameworks like naked objects that are geared for these tasks and like rails, play or asp.net mvc frameworks, can quickly generate abstract applications quickly.